sstyphi 亂說話

the S1P secreted in tumor region base on
1. high SphK level and low SPL
2. some tumor require the S1P for survival

but the S1P also is the lipid mediator of lymphocyte, and its angoist ptoduct such as FTY720 show the immunosuppresion ability in the transplant receipiant. current article support the S1P may induce the anti-inflammatory phenotype of master cell and endotheial.

the S1P showed the common inhibitor of lymphocyte proliferation and it also show the anti-apoptosis effect of lymphocyte via Bax inhibition.

take them together. should I claim about the tumor-secreted S1P may induce the anti-inflammatory phenotype in TIL.

the hypothesis are 1. the S1P inhibit the TIL proliferation. 2. S1P secret the cytokine as the anti-inflammatory effect.

so we can mointor the tumoral S1P inhibit the cytosis of TIL (be continued)